Andriol Info
Active Life: Less than 8 hours
Drug Class: Anabolic/Androgenic Oral Steroid
Average Dose: Men 240-320 mg/day
Acne: Low
Water Retention: Yes, in higher doses - 280-400 mg/day
High Blood Pressure: Yes - Dosage related
Liver Toxic: Low
Aromatization: Low to moderate
DHT Conversion: Yes in higher dosage
Decrease HPTA function: Low, except in higher dosages
Andriol is a unique oral testosterone product, developed by the international drug firm Organon. One of the more recently developed anabolic steroids, Andriol first became available in the early 1980's. This compound contains 40 mg of testosterone undecanoate, based in oil (oleic acid) and sealed inside a capsule. Subtracting the ester weight, this equates to a dosage of approximately 25mg of raw testosterone per cap. The design of this steroid is quite different from that of most oral steroids. Drugs administered orally generally enter the blood stream through the liver. When a steroid compound is given this way without some form of structural protection, it will be quickly broken down during the "first pass". This process leaves very little steroid intact, basically deactivating the drug. Adding a methyl group (c-17 AA) to the structure is one way to protect it from this process, however stress is also placed on the liver as a result. In some instances this stress can lead to actual damage to liver tissues, so the designers of this steroid sought another way to protect the testosterone molecule. With Andriol , this was accomplished by making a form of testosterone that would be absorbed through the lymphatic system. This is due to its high fat solubility brought about by the ester, and its suspension in oil. Having the compound absorbed this way was thought to be very advantageous, as it allows the steroid to bypass the destructive first-pass through liver. This should permit the compound to enter the blood stream intact, without the need for a harsh chemical alteration. The ester breaks off once it is in circulation of course, yielding free active Pharmacokinetics of Oral Testosterone. In design this steroid appears to be undecanoate that of a completely liver safe and orally active form of testosterone.
The disadvantage of Andriol is that it only becomes effective if taken in high doses. Even if a dose of 200 mg of Andriol/day is taken, the testosterone level in the blood is still too low for a bodybuilder to gain strength and muscle growth. The capsules, therefore, are effective for only a few hours so that 6-7 capsules, that is 240-280 mg (mini-mum), must be taken daily to achieve good results comparable to those of injectable compounds. This, however, puts the athlete in a dosage range which begins to influence the hormone production and the compound now more readily converts into estrogen. Such a dose can also manifest itself in a higher retention of sodium and water. This is one factor which competing athletes must consider. Another disadvantage is Andriol's high price. A package with 60 capsules costs approximately $80 and the minimum daily dose of 6-7 capsules thus costs almost $8. For those athletes who would like to try Andriol 8 capsules (320 mg daily) should be taken. The capsules should be taken three times daily (approximately every 8 hours) after meals so that the substance can be properly reabsorbed. However, even this high dosage does not guarantee satisfactory re-sults. Those of you who believe that you need even higher doses should then consider that it might be more sensible to switch to the injectable testosterone. The Andriol/ Oxandrolone stack gives athletes who do not yet have much experi-ence with steroids a fairly large strength increase and also often substantial muscle growth. Andriol is quickly eliminated by the body it should also be considered for use before competitions requir-ing doping tests. Women should avoid Andriol since the androgenic component-common with testosterone-is also strongly developed in this compound. Andriol intake can occasionally lead to high blood pressure, retention of fluids, acne, sexual overstimulation, and, in women, the well-known virilization symptoms.
Andriol Side effects
Andriol is the safest of all testosterones. Natural ester added to a synthetic derivative which will nor change liver enzymes. No testicular shrinkage, no reduction on in spermatogenesis will occur whith resonable dosages.
Andriol effects and Andriol dosage
On paper Andriol seems like an ideal oral testosterone product . Andriol is clean, safe and worlds apart from other oral testosterone derivatives like the crude methyltestosterone. But as we always hear in life, if it looks to good to be true, it probably is. And there are definitely some issues with Andriol. The first problem is that bioavailability, although clearly worlds apart from trying to take straight testosterone orally, is probably not significant next to c17alpha alkylated orals. Athletes typically find that in doses of Andriol less than 240mg per day (6 capsules) effects are generally not seen at all. 240mg of testosterone ester daily, the primary male androgen, and only a meager effect. When doses of Andriol go higher, maybe 8-10 capsules (320-400mg), new muscle growth is slight to moderate at best, but no incredible bulky gains are ever reported. Logic leads one to think that only a little testosterone is making its way into circulation. Testosterone is a powerful hormone no matter what the ester or form of administration. If it were active in the blood stream, the results would have to be pronounced.
Andriol's estrogen conversion and Andriol side effects
One might also pay interest to the "mildness" of this compound as described by other bodybuilding materials. Andriol is often spoken about as some type of magic product , which to spite being a form of regular testosterone somehow allows for only minimal estrogen conversion. You should know that the way a drug is administered includes a number of factors that can slightly alter its effect, the most predominant being the speed of release. This effects the time it takes for a peak blood level to be reached, and likely the length it takes to see results. The primary reason Testosterone suspension seems more powerful than enanthate is because more drug is active on day one. At the same time estrogen builds up faster and side effects become pronounced very quickly. The ester is also part of the total weight, and 100mg testosterone contains a much larger quantity of testosterone molecules that testosterone plus ester, another reason for varying effect. But these changes do not amount to all that much. The structure of testosterone is what allows it to break down into estrogen. The only way we can really prevent an androgen from converting to estrogen is to change the base molecule, not the ester. Once free in the blood stream we cannot prevent testosterone from being aromatized without interfering with the aromatase enzyme itself. The lack of results and side effects often reported with Andriol must be going hand in hand with poor absorption.
Most athletes today consider Andriol a very poor buy. I know other references do find use for Andriol (testosterone undecanoate) , which is defendable because some amount of steroid clearly does enter the blood stream in tact. Technically it is still an oral testosterone, and definitely does not carry the same liver-toxicity risks associated with most steroids designed for this type of administration, so all is not Post. Those specifically looking for a mild oral at times do purchase Andriol, and occasionally are even satisfied with their results. But for most its high price and required high daily dosages usually causes them to avoided it when crossing it on the black market. Besides, if we want a mild steroid the last thing we really should shop for is a testosterone.
